崔建国

2016年09月23日 浏览量: 评论(0) 来源: 化学与材料科学学院 作者: 化学与材料科学学院

崔建国 简历

广西师范学院,化学与材料科学学院,教授

教育经历

1.1996/9–1999/7 中山大学,有机化学, 博士

2.1986/9–1989/7 北京师范大学,有机化学, 硕士

3.1978/2–1982/2 中山大学,有机化学, 学士

科研与学术工作经历

1.1999/12-至今,广西师范学院,化学与材料科学学院,教授

2.2007/2-2007/8,美国Cleveland州立大学,化学系,访问研究员

3.1992/12-1999/11,广西师范学院,化学系,副教授

4.1993/10-1994/10,日本东京大学,化学系,访问学者

5.1989/1-1992/11,广西师范学院,化学系,讲师

6.1982/2-1988/12,广西师范学院,化学系,助教

主持或参加科研项目(课题)及人才计划项目情况:

1. 国家自然科学基金地区基金项目,21462009,具有特殊甾核结构甾体杂环化合物的设计、合成及生物活性评估,2015/01-2018/.12, 50万元,在研,参加

2. 广西自然科学基金重点基金项目,2010GXNSFD013019,甾体内酰胺化合物的合成、表征及其抗肿瘤活性研究,2010/03-2013/03, 30万元,已结题,主持

3. 国家自然科学基金地区基金项目,20562001,海洋生物中具有抗肿瘤和抗病毒活性的多羟基甾醇及其硫酸酯钠盐的合成和它们的构效关系研究,2006/01-2008/1220万元,已结题,主持

4. 国家自然科学基金地区基金重点项目,30160095,广西五种抗癌中草药有效化学成分和构效关系研究,2002/01-2004/1260万元,已结题,参加

5. 国家自然科学基金项目,29160004,萜烯类硫醇化合物及其衍生物的合成与应用研究,1992/01-1994/12 2万元,已结题,主持

代表性研究成果和学术奖励情况

一、期刊论文

1. 第一作者论文

(1) 崔建国刘畅, 刘亮,甘春芳, 卢艳, 陈爽, 董新, 黄燕敏(*). 3-羟基-6-腙及6-羰基-3-腙胆甾烷的合成及抗肿瘤活性评估,有机化学20163612):2933~2940

(2) 崔建国,赵丹丹,何冬梅,黄燕敏(*),刘志平,林啟福,石海信,甘春芳(*) ,去氢表雄酮噻唑衍生物的合成及抗肿瘤活性评估,有机化学2016363):630~637

(3) Jianguo CuiQifu LinChunfang GanJunyan ZhanWei Su, Dandan ZhaoBinbin QiYanmin Huang(*)Synthesis and antiproliferative evaluation of some novel B-nor-D-homosteroidsSteroids201598138~142

(4) Jianguo CuiQifu LinYanmin Huang(*)Chunfang GanQiucui YaoYingliang WeiQi XiaoErbin KongDesign, Synthesissynthesis and Antiproliferative Evaluation antiproliferative evaluation of Some B-Homo Steroidal LactamsMedicinal Chemistr Resrarch2015247):2906~2915

(5) Jianguo CuiBinbin QiChunfang GanZhipin LiuHu HuangQifu LinDandan ZhaoYanmin Huang(*)Synthesis and in vitro antiproliferative evaluation of some B-norcholesteryl benzimidazole and benzothiazole derivativesMarine Drugs2015132488~2504

(6) Jianguo CuiLiang LiuDandan ZhaoChunfang GanXin HuangQi XiaoBinbin QiLei YangYanmin Huang(*)Synthesis, characterization and antitumor activities of some steroidal derivatives with side chain of 17-hydrazone aromatic heterocycleSteroids20159595):32~38

(7) 崔建国,赵丹丹,何冬梅,黄燕敏(*),刘志平,林啟福,石海信,甘春芳,去氢表雄酮噻唑衍生物的合成及抗肿瘤活性评估,有机化学2015,(03):630~637

(8) Cui JianguoLin QifuGan ChunfangYao QiucuiSu WeiHuang Yanmin(*)Synthesis and cytotoxic activity of some 4,6-diaza-A,B-dihomo-steroid bilactamsSteroids20147914~18

(9) 崔建国,刘亮,甘春芳,肖琦,黄燕敏(*),芳()环甾体化合物的合成及生理活性研究,化学进展2014262/3):414~419

(10) 崔建国,黄立梁,黄燕敏(*),范建春,一种具有抗肿瘤活性胆酸衍生物的合成新方法,有机化学20092906):971~974

(11) Cui Jian-GuoFan LeiHuang Li-LiangLiu Hong-LiZhou Ai-Min(*)Synthesis and evaluation of some steroidal oximes as cytotoxic agents: Structure/activity studies (I)Steroids2009741):62~72

(12) Cui JianguoFan LeiHuang YanminXin YiZhou Aimin(*)Synthesis and evaluation of some steroidal oximes as cytotoxic agents: Structure/activity studies (II)Steroids20097412):989~995

(13) Cui JianguoWang HuiHuang YanminXin YiZhou Aimin(*)Synthesis and cytotoxic analysis of some disodium 3β,6β-dihydroxysterol disulfatesSteroids20097413-14):1057~1060

(14) Cui JianguoHuang, LiliangFan, LeiZhou, Aimin(*)A facile and efficient synthesis of some (6E)-hydroximino-4-en-3-one steroids, steroidal oximes from Cinachyrella spp. spongesSteroids2008733):252~256

(15) 崔建国,钟益宁,甘春芳,黄初升,左旋多巴Schiff碱的合成及其不对称相转移催化烷基化,有机化学20082801):78~83

(16) 崔建国,冯瑞,李若华,甘春芳,钟益宁,从天然左旋多巴合成卡比多巴,精细化工20072404):387~391

(17) 崔建国,曾陇梅(*),苏镜娱,多羰基甾酮的选择性还原反应研究,高等学校化学学报20032404):639~642

(18) 崔建国,曾陇梅(*),苏镜娱,何小玉,24-亚甲基胆甾-4--3β,6α-二醇的结构表征,有机化学20022207):515~518

(19) Cui JGZeng LM(*)Su JYLin CWRegio- and stereo-selective reductions of steroidal 4-en-3, 6-dioneChemical Res. in Chinese Uni.2002184):400~404

(20) Cui JGLin CWZeng LM(*)Su JYSynthesis of polyhydroxysterols (III): synthesis and structural elucidation of 24-methylenecholest-4-en-3β,6α-diolSteroids20026713-14):1015~1019

(21) Cui JGZeng LM(*)Su JYLu WGSynthesis of polyhydroxysterols (I): synthesis of 24-methylenecholest-4-en-3 beta,6 beta-diol, a cytotoxic natural hydroxylated sterolSteroids2001661):33~38

(22) 崔建国,曾陇梅(*),苏镜娱,彭文烈,徐安龙,多羟基甾醇的合成及其结构与抗肿瘤细胞活性关系研究,高等学校化学学报20002109):1399~1404

(23) 崔建国,晏日安,曾陇梅,酮的不对称还原,有机化学1998186):521~524

(24) Cui JianguoZeng Longmei(*)Su JingyuThe Ozonization of Stigmast-4,22-dien-3,6-dioneChemical Res. in Chinese Uni.1998,(4):423~425

(25) 崔建国,新井则義,CAN作用下脂肪族含氮化合物的游离基反应研究,有机化学19961606):544~550

(26) 崔建国,俞凌翀(*),不对称Michael反应在有机合成中应用的进展,有机化学19911105):449~456

(37) Cui JianguoYu Lingchong(*)Research on Asymmetric Michael Addition, Part II: Addition of the Menthone Imine of Ethyl Glycinate to Ethyl Acrylate under PTC ConditionSynth. Commun.19902018):2895~2900

(38) Cui JianguoYu Lingchong(*)Research on Asymmetric Michael Addition, Part I: Addition of Menthone Imines of Glycinates to Alkyl Acrylates under the Solid Base ConditionsSynth. Commun.19902018):2887~2893

 

2. 通讯作者论文(勿与第一作者论文重复)

(1) 黄燕敏,戚斌斌,崔建国(*),甘春芳,杨春晖,刘畅,陈爽,石海信,某些B-降胆甾噻唑化合物的合成及抗肿瘤活性研究,有机化学2016,(07):1602~1610

(2) Yanmin HuangErbin KongChunfang GanZhiping LiuQifu LinJianguo Cui(*)Synthesis and antiproliferative activity of steroidal thiosemicarbazone platinum (Pt (II)) complexesBioinor. Chem. & Applica.20152015Article ID 742592):1~7

(3) 黄燕敏,姚秋翠,刘志平,甘春芳,郑嘉桦,盛海兵,石海信,崔建国(*),鹅脱氧胆酸含氮衍生物的合成及抗肿瘤活性研究,有机化学20153510):2168~2175

(4) 黄燕敏,刘亮,戚斌斌,赵丹丹,杨雷,甘春芳,崔建国(*)7β-羟基表雄酮的选择性合成,有机化学2015351):241~245

(5) Chunfang GanJianguo Cui(*)Shaoyang SuQifu LinLinyi JiaLianghua FanYanmin HuangSynthesis and Antiproliferative Activity of Some Steroidal Thiosemicarbazones, Semicarbazones and HydrozonesSteroids20148787):99~107

(6) Yanmin HuangQiucui YaoJianguo Cui(*)Chunfang GanQianyang HuangBing SuAimin ZhouSyntheses of lactam derivatives of chenodeoxycholic acid and in vitro antiproliferative activityChemical Res. in Chinese Uni.20143004):605~613

(7) Gan ChunfangLin QifuCui Jianguo(*)Feng JidanGuoJinniLiao HuoyingHuang Yanmin(*)Synthesis and in vitro antiproliferative evaluation of some novel B-norcholesterolsSteroids20147937~43

(8) 黄燕敏,苏绍烊,贾琳怡,甘春芳,林啟福,孔二斌,崔建国(*),某些甾体肟醚化合物的合成及抗肿瘤活性研究,有机化学20143409):1816~1828

(9) Huang YanminCui Jianguo(*)Chen SijingLin QifuSong HuacanGan ChunfangSu BinZhou AiminSynthesis and Evaluation of Some New Aza-B-homocholestane Derivatives as Anticancer AgentsMarine Drugs2014124):1715~1731

(10) 甘春芳,盛海兵,戚斌斌,杨雷,赵丹丹,黄燕敏,崔建国(*),具有特殊甾核结构甾体化合物的合成及生理活性研究进展,有机化学20143409):1730~1742

(11) Huang YanminCui Jianguo(*)Chen SijingGan ChunfangYaoQiucuiLin QifuSynthesis and antiproliferative activity of C-homo-lactam derivatives of 7-deoxycholic acidBioorg. Med. Chem. Lett.2013237):2265~2267

(12) Huang YanminCui Jianguo(*)Li YingFan LeiJiao YanxiaoSu ShaoyangSyntheses and antiproliferative activity of some sulfated hydroximinosterolsMed. Chem. Res.2013221):409~414

(13) Yanmin HuangJianguo Cui(*)Ying LiLei FanYanxiao JiaoShaoyang SuSyntheses and antiproliferative activity of some sulfated hydroximinosterolsMed Chem Res2013221):409~414

(14) Yanmin HuangJianguo cui(*)Sijing ChenChunfang GanQiucui YaoQinfu LinSynthesis and antiproliferative activity fo C-Homo-lactam derivatives of 7-deoxycholic acidBioorg. Med. Chem. Lett.2013237):2265~2267

(15) Huang YanminCui Jianguo(*)Jia LinyiGan ChunfangSong HuacanZeng ChunZhou AiminSynthesis and Evaluation of Some 17-Acetamidoandrostane and N, N-Dimethyl-7-deoxycholic Amide Derivatives as Cytotoxic Agents: Structure/Activity StudiesMolecules2013187):7436~7447

(16) 黄燕敏,崔建国(*),甘春芳,姚秋翠,贾琳怡,具有生理活性的甾体酰胺类化合物,化学进展2012,(01):61~69

(17) Gan ChunfangCui Jianguo(*)Huang YanminJia LinyiWeiWanxinSynthesis and antiproliferative activity of some steroidal lactone compoundsSteroids2012773):255~259

(18) Huang YanminCui Jianguo(*)Zheng QiaoxiaZeng ChunChen QuanZhou Aimin6-Hydroximino-4-aza-A-homo-cholest-3-one and related analogue as a potent inducer of apoptosis in cancer cellsSteroids2012778-9):829~834

(19) Chunfang GanLianghua FanJianguo Cui(*)Yanmin HuangYanxiao JiaoWanxin WeiSynthesis and in vitro antiproliferative evaluation of some ring B abeo-sterolsSteroids2012771061~1068

(20) 林啟福,崔建国(*),甘春芳,刘亮,姚秋翠,黄燕敏,海洋生物中具有生理活性的多羟基甾醇,有机化学20123212):2214~2222

(21) Huang YanminCui Jianguo(*)Zhong ZhengguoGan ChunfangZhang WenyanSong HuacanSynthesis and cytotoxicity of 17a-aza-D-homo-androster-17-one derivativesBioorg. Med. Chem. Lett.20112112):3641~3643

(22) Huang YanminCui Jianguo(*)Chen SijingGan ChunfangZhou AiminSynthesis and antiproliferative activity of some steroidal lactamsSteroids20117612):1346~1350

(23) 陈思静,崔建国(*),李莹,范良华,具有生理活性甾体腙类化合物的研究进展,有机化学2011,(02):187~192.

(24) Yanmin HuangSijing ChenJianguo Cui(*)Chunfang GanZhiping LiuYingliang WeiHuachan SongSynthesis and cytotoxicity of A-homo-lactam derivatives of cholicacid and 7-deoxycholic acidSteroids201176690~694.

(25) 黄燕敏,李莹,崔建国(*),王辉,范良华,6-羟基-3-硫酸酯钠甾体化合物的合成及生理活性研究,有机化学2010,(11):1689~1694.

(26) 张晓佳,崔建国(*),李莹,陈思静,具有生理活性甾体肟类化合物的研究进展,有机化学2010,(05):655~661.

 

 二、专著

(1) 崔建国,黄燕敏,甘春芳,现代甾体化学,科学出版社, 2014.03.01

 

三、授权发明专利

(1) 崔建国,刘亮,黄燕敏,甘春芳,黄珊,林启福,3-羟基胆甾-6-酮芳香醛吖嗪甾体化合物及其合成方法和在制备抗肿瘤药物中的应用,2015.04.15,中国,ZL 201310186120.0

(2) 崔建国,戚斌斌,黄燕敏,甘春芳,刘志平,一种B-降胆甾烷苯并咪唑类化合物及其制备方法和用途,2014.12.17,中国,ZL 201410786854.7

(3) 崔建国,刘亮,黄燕敏,甘春芳,肖琦,孔二斌,去氢表雄酮芳香醛吖嗪甾体化合物及其合成方法和在制备抗肿瘤药物中的应用,2013.05.19,中国,ZL 201310184257.2

(4) 崔建国,刘亮,黄燕敏,甘春芳,肖琦,黄新,孕烯醇酮芳香醛吖嗪甾体化合物及其合成方法和在制备抗肿瘤药物中的应用,2013.05.19,中国,ZL 201310184358.X

(5) 黄燕敏,崔建国,焦艳晓,甘春芳,甾体锌金属配合物及其制备方法和在制备抗肿瘤药物中的应用,2013.05.19,中国,ZL 201310184359.4

(6) 崔建国,范良华,甘春芳,黄燕敏,B--3,6-二取代胆甾烷化合物及其制备方法和在制备抗肿瘤药物中的应用,2013.01.30,中国,ZL 201110179146.3

(7) 黄燕敏,林启福,崔建国,甘春芳,肖琦,姚秋翠,A,B-环双内酰胺甾体化合物及其合成方法和在制备抗肿瘤药物中的应用,2013.8.21,中国,ZL 201310184310.9

(8) 崔建国 ,黄燕敏,周爱民,6-取代-4-氮杂-A-homo-3-氧代甾体化合物及其在制备抗肿瘤药物中的应用,2012.7.25,中国,ZL 201010107528.0

 

四、学术奖励

1. 2003.12科研项目广西单萜类芳香资源深度利用的理论研究获广西区人民政府授予广西壮族自治区科技进步二等奖(第一完成人);

2. 2004.12 科研项目具有抗肿瘤活性多羟基甾醇的合成研究获广西区人民政府授予广西壮族自治区科技进步三等奖(第一完成人);

3. 2009年科研项目广西五种抗癌中草药有效化学成分和构效关系的研究获广西区人民政府授予广西壮族自治区科技进步三等奖(排名第三);

4. 2011科研项目具有抗肿瘤活性甾体硫酸酯钠盐及肟类化合物的合成及抗肿瘤活性评估 获广西区人民政府授予广西壮族自治区自然科学奖二等奖(第一完成人);

5. 2016年科研项目具有扩环及缩环甾核结构甾体化合物作为抗肿瘤药物的合成和评估获广西壮族自治区自然科学奖三等奖(第二完成人,已经通过公示)。