肖琦

2016年09月23日 浏览量: 评论(0) 来源: 化学与材料学院 作者: 肖琦

                                                                                  

学历、职称:博士、研究员/博士生导师(分析化学)硕士生导师(分析化学、学科教学(化学))

职务:院长

兼职:广西高等教育学会化学专业委员会常务理事、副主任委员;广西化学化工学会理事;中国化学会会员;中国毒理学会会员;中国化工学会专家库专家;广西天然高分子化学与物理重点实验室培育基地常务副主任;广西师范学院学术委员会委员、教学指导委员会委员、学位评定委员会委员、工会第八届委员会委员。

专业方向:纳米材料生物效应; 

小分子与生物大分子相互作用机制;

生命电分析化学;

纳米生物传感器。
 话:0771-3908065
Emailqi.xiao@whu.edu.cn

教育与研究经历

2001-2005 武汉大学应用化学专业,获理学学士学位;

2005-2010 武汉大学物理化学专业,获理学博士学位(硕博连读);

2009-2010 香港浸会大学化学系交流博士生;

2010-2011 美国马萨诸塞大学化学系,博士后;

201110月至今 广西师范学院化学与材料科学学院,副教授(2012),硕士生导师(2013),研究员(2014),博士生导师(2016年,西南大学)

长期从事新型低毒量子点等纳米材料制备及其生物效应,抗肿瘤药物小分子与生物大分子相互作用机制及生命电分析化学研究。以第一作者或通讯作者在Anal. Chem.Chem. Commun.J. Hazard. Mater.Sensor. Actuat. B: Chem.等国外著名SCI刊物上发表论文50多篇,已被30 多个国家的同行在Nat. Nanotechnol., Chem. Rev.J. Am. Chem. Soc.ACS Nano 50余种SCI 收录刊物正面评价和引用超过1000次,其中单篇最高SCI 引用150次,1篇论文被ESI列为高被引论文。相关研究成果已申请国家发明专利60余项,获授权30,转让6受邀为Nanoscale, Biosens. Bioelectron., Carbon, Phys. Chem. Chem. Phys., Colloids Surf. B, Nanotechnology30多种国际SCI学术期刊评审相关稿件。目前主持和参与国家和省部级项目10余项。2014年入选广西高等学校优秀中青年骨干教师培养工程第二期培养对象。2017年入选广西高等学校高水平创新团队及卓越学者计划。2017年获得广西自然科学奖三等奖1(排名第一)

教学情况

主讲本科生基础课《物理化学》、《结构化学》和专业选修课《科学研究方法概论》;研究生学位课《材料化学》和《现代分析化学》。指导研究生获得自治区级研究生创新项目3项,指导研究生获得国家奖学金5人,自治区优秀毕业研究生2人;指导本科生获得广西高校大学生化学化工类论文及设计竞赛一等奖2项、二等奖2项、三等奖1项,获得国家大学生创新创业训练计划项目4项和广西大学生创新创业训练计划项目4项,获得第六届挑战杯广西大学生课外学术科技作品竞赛二等奖和三等奖各1项。

荣誉称号

12018年广西五一劳动奖章

22018年广西青年五四奖章

32017年广西自然科学奖三等奖(1完成人)

42017年第十四届广西青年科技奖

52017年广西自然科学基金-杰出青年基金获得者

62017年广西高等学校卓越学者

72016年广西师范学院优秀共产党员

82015年广西师范学院科研管理工作先进个人

92014-2015学年度广西师范学院教学管理先进个人

102012-2015学年度广西师范学院三育人先进个人

112014年度广西师范学院优秀班主任

122013年度广西师范学院优秀班主任

承担项目与课题

主持在研项目:

(1) 国家自然科学基金地区基金项目,线粒体作为氧化石墨烯生物效应作用靶点的热力学诠释及其分子机制研究,项目号:2176300538万。

(2国家自然科学基金地区基金项目,基于生物热力学方法的功能化氧化石墨烯与蛋白质相互作用机制研究,项目号:2156300648.5万。

(3广西自然科学基金杰出青年基金项目生物热化学项目号:2017GXNSFFA19800560

(4广西自然科学基金青年基金项目,基于生物热力学方法的I-VI型近红外发光量子点与蛋白质相互作用机制研究,项目号:2016GXNSFBA3801185万。

(5) 2017年广西高等学校高水平创新团队及卓越学者,“量子点生物效应物理化学基础”,120

主持结题项目:

(1国家自然科学基金青年基金项目,系列表面功能化量子点与线粒体相互作用机理研究,项目号:2120303524万。

(2广西自然科学基金回国基金项目,系列表面功能化量子点对线粒体功能影响的热力学及其分子机制研究,项目号:2013GXNSFCA01900510万。

(3广西高校科研项目重点项目,基于化学热力学的新型功能化量子点生物效应检测技术,项目号:ZD20140816万。

(4病毒学国家重点实验室开放课题,基于荧光纳米量子点探针的细小病毒-细胞相互作用机制研究,项目号:2014KF0066万。

(5) 广西高等学校优秀中青年骨干教师培养工程第二期培养对象,18万。

 主要学术论文(通讯作者)

2018

1. Yuanyuan Chang(常园园), Mengyao Li, Zhongyu Wu, Ying Zhuo, Yaqin Chai, Qi Xiao*,  Ruo Yuan*. Homogeneous Entropy Catalytic-Driven DNA Hydrogel as Strong Signal Blocker for Highly Sensitive Electrochemical Detection of Platelet-Derived Growth Factor. Analytical Chemistry 2018, 90, 82418247. (SCI一区,IF=6.042)

2. Shan Huang, Erli Yang(杨二利), Yi Liu, Jiandong Yao, Wei Su, Qi Xiao*. Low-temperature rapid synthesis of nitrogen and phosphorusdual-doped carbon dots for multicolor cellular imaging andhemoglobin probing in human blood. Sensors and Actuators B 2018, 265, 326334. (SCI一区,IF=5.667)

3. Shan Huang, Mengmeng Feng(冯萌萌), Jiawen Li, Yi Liu, Qi Xiao*. Voltammetric determination of attomolar levels of a sequence derived from the genom of hepatitis B virus by using molecular beacon mediated circular strand displacement and rolling circle amplificationr. Microchimica Acta 2018, 185, 206 (SCI二区,IF=5.705, 引用次数: 1)

4. Shan Huang, Erli Yang(杨二利), Jiandong Yao, Yi Liu, Qi Xiao*. Carbon dots doped with nitrogen and boron as ultrasensitive fluorescent probes for determination of α-glucosidase activity and its inhibitors in water samples and living cells. Microchimica Acta 2018, 185, 394. (SCI二区,IF=5.705, 引用次数: 1)

5. Shan Huang, Erli Yang(杨二利), Jiandong Yao, Yi Liu, Qi Xiao*. Red emission nitrogen, boron, sulfur co-doped carbon dots for “on-off-on” fluorescent mode detection of Ag+ ions and L-cysteine in complex biological fluids and living cells. Analytica Chimica Acta 2018, 1035, 192202. (SCI二区,IF=5.123)

6. Qi Xiao, Jinrong Feng(冯金荣), Jiawen Li, Mengmeng Feng, Shan Huang*. A label-free and ultrasensitive electrochemical aptasensor for lead(II) using a N,P dual-doped carbon dot-chitosan composite as a signal-enhancing platform and thionine as a signaling molecule. Analyst 2018, 143, 47644773. (SCI二区,IF=3.864)

7. Shan Huang, Erli Yang(杨二利), Lumin Wang, Yi Liu, Jiangning Xie, Baoqing Hu, Qi Xiao*. Carbon dots-based frequency-doubling scattering probes for the ultrasensitive and highly selective determination of hemoglobin. Analytical Methods 2018, 10, 891899. (SCI)

8. Qi Xiao, Mengmeng Feng(冯萌萌), Yi Liu, Shuangyan Lu, Yingzi He, Shan Huang*. The graphene/polypyrrole/chitosan-modified glassy carbon electrode for electrochemical nitrite detection. Ionics 2018, 24, 845859. (SCI) 

9. Qi Xiao, Yu Liang(梁瑜), Yi Liu, Shuangyan Lu, Shan Huang*. Comparison of molecular interactions of Ag2Te and CdTe quantum dots with human serum albumin by spectroscopic approaches. Luminescence 2018, 33, 181189. (SCI)

10. Shan Huang, Yu Liang(梁瑜), Jianguo Cui*, Jiangning Xie, Yi Liu, Baoqing Hu, Qi Xiao**. Comparative investigation of binding interactions with three steroidal derivatives of d(GGGT)4 G-quadruplex aptamer. Steroids 2018, 132, 4655.

2017

1.Shan Huang, Lumin Wang(王鲁敏), Chusheng Huang, Wei Su, Qi Xiao*. Label-free and ratiometric fluorescent nanosensor based on amino-functionalized graphene quantum dots coupling catalytic G-quadruplex/hemin DNAzyme for ultrasensitive recognition of human telomere DNA. Sensors and Actuators B 2017, 245, 648−655. (SCI一区,IF=5.667, 引用次数: 6)

2. Qi Xiao, Yu Liang(梁瑜), Fawei Zhu, Shuangyan Lu, Shan Huang*. Microwave-assisted one-pot synthesis of highly luminescent N-doped carbon dots for cellular imaging and multi-ion probing. Microchim Acta 2017, 184, 2429–2438. (SCI二区,IF=5.705, 引用次数: 10)

3. Qi Xiao, Shuangyan Lu(卢双燕), Chusheng Huang, Wei Su, Shuyu Zhou, Jiarong Sheng, Shan Huang*. An electrochemical chiral sensor based on aminofunctionalized graphene quantum dots/β-cyclodextrin modified glassy carbon electrode for enantioselective detection of tryptophan isomers. Journal of the Iranian Chemical Society 2017, 14, 1957–1970. (SCI, 引用次数: 2)

4. Shan Huang, Jiangning Xie(谢江宁), Jianguo Cui*, Liang Liu, Yu Liang, Yi Liu, Qi Xiao**. Comparative investigation of binding interactions between three steroidal compounds and human serum albumin: Multispectroscopic and molecular modeling techniques. Steroids 2017, 128, 136146. (SCI, 引用次数: 2)

5. Shan Huang, Jiangning Xie(谢江宁), Wei Su, Yi Liu, Xiaohui Wang, Baoqing Hu, Qi Xiao*. Comparative investigation of interactions between two ruthenium(II) arene PTA type complexes with curcuminoid ligands and human serum albumin. Journal of Organometallic Chemistry 2017, 853, 8192. (SCI, 引用次数: 1)

2016

1. Shan Huang, Shuangyan Lu(卢双燕), Chusheng Huang, Jiarong Sheng, Lixia Zhang, Wei Su, Qi Xiao*. An electrochemical biosensor based on single-stranded DNA modified gold electrode for acrylamide determination. Sensors and Actuators B 2016224, 22–30. (SCI一区, IF= 5.667, 引用次数: 13)

2. Shan Huang, Lumin Wang(王鲁敏), Chusheng Huang, Wei Su, Qi Xiao*. Amino-functionalized graphene quantum dots based ratiometric fluorescent nanosensor for ultrasensitive and highly selective recognition of horseradish peroxidase. Sensors and Actuators B 2016, 234, 255–263. (SCI一区, IF= 5.667, 引用次数: 10)

3. Shan Huang, Shushu Peng, Wei Su, Zhaofeng Tang, Jianguo Cui, Chusheng Huang, Qi Xiao*. In vitro interaction investigation between three Ru(II) arene complexes and human serum albumin: Structural influences. RSC Advances 20166, 47043–47054. (SCI二区, IF= 3.108, 引用次数: 7)

4. Shan Huang, Hangna Qiu(丘杭娜), Jiangning Xie, Chusheng Huang, Wei Su, Baoqing Hu, Qi Xiao*. Systematical investigation of in vitro molecular interaction between fluorescent carbon dots and human serum albumin. RSC Advances 20166, 44531–44542. (SCI二区, IF= 3.108, 引用次数: 18)

5. Shan Huang, Lumin Wang(王鲁敏), Chusheng Huang, Baoqing Hu, Wei Su, Qi Xiao*. Graphene quantum dot coupled with gold nanoparticle based “off-on” fluorescent probe for sensitive and selective detection of L-cysteine. Microchimica Acta 2016183, 18551864. (SCI二区, IF= 5.705, 引用次数: 15)

6. Shan Huang, Hangna Qiu(丘杭娜), Yi Liu, Chusheng Huang, Jiarong Sheng, Jianguo Cui, Wei Su, Qi Xiao*. Systematical investigation of in vitro interaction of InP/ZnS quantum dots with human serum albumin by multispectroscopic approach. Colloids and Surfaces B 2016148, 165172. (SCI二区, IF= 3.887, 引用次数: 5)

7. Qi Xiao, Shuangyan Lu(卢双燕), Chusheng Huang, Wei Su, Shan Huang*. Novel N-doped carbon dots/β-cyclodextrin nanocomposites for enantioselective recognition of tryptophan enantiomers. Sensors 2016, 16, 1874. (SCI, IF= 2.677, 引用次数: 5)

8. Shan Huang, Shushu Peng, Fawei Zhu, Xiaolin Lei, Qi Xiao*, Wei Su, Yi Liu, Chushgeng Huang, Lixia Zhang. Multispectroscopic investigation of the interaction between two ruthenium(II) arene complexes of curcumin analogs and human serum albumin. Biological Trace Element Research 2016169, 189203. (SCI, IF=2.399, 引用次数: 2)

9. Shan Huang, Yu Liang(梁瑜), Chusheng Huang, Wei Su, Xiaolin Lei, Yi Liu, Qi Xiao*. Systematical investigation of binding interaction between novel ruthenium(II) arene complex with curcumin analogs and ctDNA. Luminescence 2016, 31, 13841394. (SCI, IF=1.509, 引用次数: 2)

2015

1. Shan Huang, Hangna Qiu(丘杭娜), Shuangyan Lu, Fawei Zhu, Qi Xiao* Study on the molecular interaction of graphene quantum dots with human serum albumin: Combined spectroscopic and electrochemical approaches. Journal of Hazardous Materials 2015285, 18–26. (ESI高被引论文SCI一区, IF= 6.534引用次数:47)

2. Shan Huang, Lumin Wang(王鲁敏), Chusheng Huang, Jiangning Xie, Wei Su, Jiarong Sheng, Qi Xiao* A carbon dots based fluorescent probe for selective and sensitivedetection of hemoglobin. Sensors and Actuators B 2015221, 1215–1222. (SCI一区, IF= 5.667, 引用次数: 25)

3. Shan Huang, Hangna Qiu(丘杭娜), Yi Liu, Chusheng Huang, Jiarong Sheng, Wei Su, Qi Xiao*. Molecular interaction investigation between three CdTe:Zn2+ quantum dots and human serum albumin: A comparative study. Colloids and Surfaces B 2015136, 955–962. (SCI二区, IF= 3.887, 引用次数: 15)

4. Shan Huang, Hangna Qiu(丘杭娜), Fawei Zhu, Shuangyan Lu, Qi Xiao*. Graphene quantum dots as on-off-on fluorescent probes for chromium(VI) and ascorbic acid. Microchimca Acta 2015182, 1723–1731. (SCI二区, IF= 5.705, 引用次数: 47)

5. Shan Huang, Shuangyan Lu(卢双燕), Chusheng Huang, Jiarong Sheng, Wei Su, Lixia Zhang, Qi Xiao*. Sensitive and selective stripping voltammetric determination of copper(II) using a glassy carbon electrode modified with amino-reduced graphene oxide and β-cyclodextrin. Microchimica Acta 2015, 182, 2529–2539. (SCI二区, IF=5.705, 引用次数: 11)

6. Shan Huang, Lumin Wang(王鲁敏), Fawei Zhu, Wei Su, Jiarong Sheng, Chusheng Huang, Qi Xiao* A ratiometric nanosensor based on fluorescent carbon dots for label-free and highly selective recognition of DNA. RSC Advances 20155, 44587–44597. (SCI二区, IF=3.108, 引用次数: 27)

7. Shan Huang, Fawei Zhu(朱发伟)Qi Xiao*, Yu Liang, Quan Zhou, Wei Su*. Thermodynamic investigation of the interaction between the [(h6-p-cymene)Ru(benzaldehyde-N4-phenylthiosemicarbazone)Cl]Cl anticancer drug and ctDNA: multispectroscopic and electrochemical studies. RSC Advances 20155, 42889–42902. (SCI二区, IF=3.108, 引用次数: 10)

8. Shan Huang, Fawei Zhu(朱发伟), Quanquan Qian, Qi Xiao*, Wei Su*. Thermodynamic investigation of interaction between [(η6-p-Cymene)RuII(Acetone-N4- Phenylthiosemicarbazone)Cl]Cl anticancer drug and human serum albumin: Spectroscopic and electrochemical studies. Biological Trace Element Research 2015164, 150–161. (SCI, IF=2.399, 引用次数: 9)

2014

1. Shan Huang, Fawei Zhu(朱发伟)Qi Xiao*, Wei Su, Jiarong Sheng, Chusheng Huang, Baoqing Hu. A CdTe/CdS/ZnS core/shell/shell QDs-based "OFF-ON" fluorescent biosensor for sensitive and specific determination of L-ascorbic acid. RSC Advances 2014, 4, 46751–46761. (SCI二区, IF=3.108引用次数:30)

2. Shan Huang, Fawei Zhu(朱发伟)Qi Xiao*, Quan Zhou, Wei Su*, Hangna Qiu, Baoqing Hu, Jiarong Sheng, Chusheng Huang. Combined spectroscopy and cyclic voltammetry investigates the interaction between [(h6-p-cymene)Ru(benzaldehyde-N(4)-phenylthiosemicarbazone)Cl]Cl anticancer drug and human serum albumin. RSC Advances 2014, 4, 36286–36300. (SCI二区, IF=3.108引用次数:20)

3. Shan Huang, Fawei Zhu(朱发伟), Hangna Qiu, Qi Xiao*, Quan Zhou, Wei Su, Baoqing Hu. A Sensitive Quantum Dots-based “OFF-ON” Fluorescent Sensor for Ruthenium Anticancer Drugs and ctDNA. Colloids and Surfaces B 2014117, 240–247. (SCI二区, IF= 3.887引用次数:22)

2013

1. Qi Xiao, Shan Huang, Wei Su, Peiyuan Li, Jianqiang Ma, Fenping Luo, Jing Chen, Yi Liu. Systematically investigations of conformation and thermodynamics of HSA adsorbed to different sizes of CdTe quantum dots. Colloids and Surfaces B 2013102, 76–82. (SCI二区, IF=3.887引用次数:44)

2. Shan Huang, Qi Xiao*, Wei Su, Peiyuan Li, Jianqiang Ma, Zhike He. Simple and Sensitive Determination of Papain by Resonance Light-Scattering with CdSe Quantum Dots. Colloids and Surfaces B 2013102, 146–151. (SCI二区, IF=3.887引用次数:14)

3. Qi Xiao, Shan Huang, Wei Su, Peiyuan Li, Yi Liu. Evaluate the potential toxicity of quantum dots on bacterial metabolism by microcalorimetry. Thermochimica Acta 2013552, 98–105. (SCI, IF= 2.236引用次数:10)

4. Qi Xiao, Hangna Qiu(丘杭娜), Shan Huang, Chusheng Huang, Wei Su, Baoqing Hu, Yi Liu. Systematic Investigation of Interactions between Papain and MPA-capped CdTe Quantum Dots. Molecular Biology Reports 201340, 5781–5789. (SCI, IF= 1.828引用次数:9)

5. Shan Huang, Jianqiang Ma, Qi Xiao*, Mingyue Dong, Xuehua Li, QiulingLuo. Direct Determinaiton of Isocarbophos by using Oil Soluble CdSe Quantum Dots as Fluorescent Probe. Spectroscopy and Spectral Analysis 201333, 2853–2857. (SCI, IF=0.275引用次数:1)

6. Shan Huang, Hangna Qiu(丘杭娜)Qi Xiao*, Chusheng Huang, Wei Su, Baoqing Hu. A Simple QD–FRET Bioprobe for Sensitive and Specific Detection of Hepatitis B Virus DNA. Journal of Fluorescence 201323, 1089–1098. (SCI, IF= 1.461, 引用次数:15)

7. Ziqiang XuLiyun YangXiaoyang FanJiancheng JinJie MeiWu PengFenglei JiangQi XiaoYi Liu*Low temperature synthesis of highly stable phosphate functionalized two color carbon nanodots and their application in cell imaging. Carbon201366, 351–360. (SCI, IF= 6.337引用次数:65)

2012

1. Qi Xiao, Shan Huang, Wei Su, WH Chan, Yi Liu. Facile synthesis and characterization of highly fluorescent and biocompatible N-acetyl-L-cysteine capped CdTe/CdS/ZnS core/shell/shell quantum dots in aqueous phase. Nanotechnology 201223, 495717. (SCI二区, IF= 3.573引用次数:26)

2. Qi Xiao, Shan Huang, Wei Su, Peiyuan Li, Yi Liu. Systematically Investigation of Interactions between BSA and Different Charge-capped CdSe/ZnS Quantum Dots. Journal of Photochemistry and Photobiology A: Chemistry 2012249, 53–60. (SCI, IF= 2.477引用次数:34)

3. Qi Xiao, Shan Huang, Wei Su, Peiyuan Li, Yi Liu. Evaluate the potential environmental toxicity of quantum dots on ciliated protozoa by microcalorimetry. Thermochimica Acta 2012547, 62–69. (SCI, IF= 1.938引用次数:7)

4. Qi Xiao, Ting Qiu, Shan Huang, Yi Liu, Zhike He. Preparation and Biological Effect of Nucleotide Capped CdSe/ZnS Quantum Dots on Tetrahymena Thermophila. Biological Trace Element Research 2012147, 346–353. (SCI, IF= 1.798, 引用次数:9)

5. Qinglian Guo, Juan. Zhang, Ziqiang Xu, Ran Li, Fenglei Jiang, Qi Xiao*, Yi Liu. Comparative study on the effects of two antifungal drugs against Candida albicans by microcalorimetry and transmission electron microscopy. Thermochimica Acta 2012, 543, 82–87. (SCI, IF=1.938引用次数:4)

6. Xiaole Han, Lu Lai, Fangfang Tian, Fenglei Jiang, Qi Xiao, Yong Li, Qiuliyang Yu, Dongwei Li, Jia Wang, Qiumeng Zhang, Bofan Zhu, Ran Li, Yi Liu. Toxicity of CdTe Quantum Dots on Yeast Saccharomyces Cerevisiae. Small 20128, 2680–2689. (SCI, IF=8.315引用次数:18)

2011年以前

1. Yong Lei, Qi Xiao (共同第一作者), Shan Huang, Wansu Xu, Zhe Zhang, Zhike He, Yi Liu, Fengjiao Deng. Impact of CdSe/ZnS quantum dots on the development of zebrafish embryos. Journal of Nanoparticle Research 201113, 6895–6906. (SCI, IF= 2.101引用次数:12 )

2. Qi Xiao, Shan Huang, Yushu Ge, Zhike He, Yi Liu, Jiangong Liang. A novel fluorescent silver ion biosensor based on nucleic acid molecular "light switch". Journal of Fluorescence 201020, 541–549. (SCI, IF=1.601, 引用次数:8)

3. Qi Xiao, Bo Zhou, Shan Huang, Fangfang Tian, Hongliang Guan, Yushu Ge, Xiaorong Liu, Zhike He, Yi Liu. Direct Observation of the Binding Process between Protein and Quantum Dots by In-situ Surface Plasmon Resonance Measurements. Nanotechnology 200920, 325101. (SCI二区, IF= 3.573引用次数:26)

4. Qi Xiao, Shan Huang, Liu Yi, Fangfang Tian, Juncheng Zhu. Thermodynamics, Conformation and Active Sites of the Binding of Zn-Nd Hetero-bimetallic Schiff Base to Bovine Serum Albumin. Journal of Fluorescence 200919, 317–326. (SCI, IF= 1.601引用次数:61)

5. Shan Huang, Qi Xiao (共同第一作者), Zhike He, Yi Liu, Philip Tinnefeld, Xiongrui Su, Xiaoniu Peng. A high sensitive and specific QDs FRET bioprobe for MNase. Chemical Communications 200845, 5990–5992. (SCI, IF= 6.567引用次数:62)

6. Qi Xiao, Shan Huang, Zude Qi, Bo Zhou, Zhike He, Liu Yi. Conformation, thermodynamics and stoichiometry of HSA adsorbed to colloidal CdSe/ZnS quantum dots. BBA-Proteins and Proteomics 20081784, 1020–1027. (SCI, IF= 3.016引用次数:137)

 

课题组合影

 

 

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