王丹

2019年03月20日 浏览量: 评论(0) 来源: 化学与材料学院 作者: 王丹

 

学历、职称:博士、助理研究员/硕士生导师(分析化学)

专业方向:

1) 功能蛋白结构及生物效应研究

2) 微生物细胞表面展示技术的应用

3) 生物传感器构建及应用

联系方式:

E-mail: wangdan1989323@126.com

 

教育与研究经历:

2007-2011 广西大学化学专业,获理学学士学位;

2011-2016 南京大学化学专业,获理学博士学位(硕博连读);

2017年2月至今 南宁师范大学化学与材料学院,助理研究员。

应用结构生物学、生物化学和分析化学的手段对金属蛋白的结构、性质、调控机制及应用展开研究。以第一作者及参与者身份在Plos pathogens、Scientific Reports、Biochemical Engineering Journal、Chemical Science、PNAS等国际学术期刊发表SCI论文10余篇。

教学情况

   主讲本科生基础课《无机化学》、《分析化学》和《仪器分析化学》。指导本科生获得广西高校大学生化学化工类论文及设计竞赛二等奖和三等奖各1项,获得国家大学生创新创业训练计划项目1项和广西大学生创新创业训练计划项目2项,获得第五届中国“互联网+”大学生创新创业大赛广西赛区铜奖1项。

承担项目与课题:

1 国家自然科学基金青年基金项目,蛋白纳米疫苗 VP6-Ferritin 高效免疫的结构基础研究,项目号:31800631,25万,在研,主持;

2 广西自然科学基金青年基金项目,线粒体靶向的汞离子基因编码类荧光探针的设计、构筑及生物成像研究,项目号:2018JJB120049,10万,在研,主持;

3  2018年度广西高校中青年教师基础能力提升项目,基于蛋白结构的金属结合肽的设计、筛选及应用,项目号:2018KY0361,3万,在研,主持;

4  广西师范学院2018年度天然高分子化学与物理重点实验室培育基地自主研究项目,汞离子全细胞生物传感器的构建及应用研究,项目号:2018ZYB05, 5万,在研,主持。

 

主要学术论文(* 通讯作者)

2020

1  Dan Wang*, Yanan Zheng, Xiaosu Fan, Lina Xu, Ting Pang, Ting Liu, Legui Liang, Shan Huang, Qi Xiao,Visual detection of Hg2+ by manipulation of pyocyanin biosynthesis through the Hg2+-dependent transcriptional activator in microbial cells,Journal of Bioscience and Bioengineering, 2020, 129 (2): 223-228

2  Shan Huang, Haimei Li, Yi Liu, Liyun Yang, Dan Wang, Qi Xiao*, Investigations of conformational structure and enzymatic activity of trypsin after its binding interaction with graphene oxide, Journal of Hazardous Materials, 2020, 392:122285

 

2019

1  Dan Wang*, Yanan Zheng, Lina Xu, Xiaosu Fan, Na Wei, Nanhao Jin, Shan Huang, Qi Xiao, Zihua Wu*,Engineered cells for selective detection and remediation of Hg2+ based on transcription factor MerR regulated cell surface displayed systems,Biochemical Engineering Journal,2019, 150: 107289

2  Zihua Wu*, Yuling Liang, Qing Guo, Keqiu Zhang, Shifang Liang, Liyun Yang, Qi Xiao, Dan Wang*, Study on selective oxidations of gold nanorod and mesoporous silica-coated gold nanorod, Journal of Materials Science, 2019, 54(11) :8133–8147

3  Qi Xiao, Jinrong Feng, Jiawen Li, Yi Liu, Dan WangShan Huang*, A ratiometric electrochemical biosensor for ultrasensitive and highly selective detection of the K-ras gene via exonuclease III-assisted target recycling and rolling circle amplification strategies, Analytical Methods, 2019,11, 4146-4156

4  Qi Xiao, Jinrong Feng, Mengmeng Feng, Jiawen Li, Yi Liu, Dan Wang, Shan Huang*, A ratiometric electrochemical aptasensor for ultrasensitive determination of adenosine triphosphate via a triple-helix molecular switch. Microchim Acta, 2019, 186: 478

5  Lina Xu*, Xiaohua Yang, Haiyang Ding, Shouhai Li, Mei Li, Dan Wang, Jianling Xia*, Synthesis of green fluorescent carbon materials using byproducts of the sulfite-pulping procedure residue for live cell imaging and Ag+ ion determination, Materials Science and Engineering: C, 2019,102:917-922

6  Xichun Liu, Qingyuan Hu, Jinmei Yang, Shanqing Huang, Tianbiao Wei, Weizhong Chen, Yafeng He, Dan Wang, Zhijun Liu, Kang Wang, Jianhua Gan, Hao Chen*, Selective cadmium regulation mediated by a cooperative binding mechanism in CadR, Proceedings of the National Academy of Sciences, 2019, 116 (41): 20398-20403

 

2017年以前

1  Dan Wang, Weizhong Chen, Shanqing Huang, Yafeng He, Xichun Liu, Qingyuan Hu, Tianbiao Wei, Hong Sang, Jianhua Gan, Hao Chen*,Structural Basis of Zn(II) Induced Metal Detoxification and Antibiotic Resistance by Histidine Kinase CzcS in Pseudomonas aeruginosa,Plos pathogens, 2017,13(7):e1006533

2  Dan Wang, Shanqing Huang, Pingying Liu, Xichun Liu, Yafeng He, Weizhong Chen, Qingyuan Hu, Tianbiao Wei, Jianhua Gan, Jing Ma*, Hao Chen*, Structural analysis of the Hg(II)-regulatory protein Tn501 MerR from Pseudomonas aeruginosa, Scientific Reports, 2016, 6: 33391 

3  Shanqing Huang, Xichun Liu, Dan Wang, Weizhong Chen, Qingyuan Hu, Wenquan Zhou, Jianhua Gan, Hao Chen*, Structural basis for the selective Pb(II) recognition of metalloregulatory protein PbrR691, Inorganic Chemistry, 2016, 55(24): 12516-12519

4  Xiang Li, Jie Xu, Dan Wang, Ye Sha, Wei Chen, Dongshan Zhou, Xiaoliang Wang, Qing Sun, Gi Xue*, Linling Li*, Low-temperature processing of polymer nanoparticles for bioactive composites, Journal of Polymer Science Part B: Polymer Physics, 2016, 54(24): 2514-2520

5  Weizhong Chen, Dan Wang, Wenquan Zhou, Hong Sang, Xichun Liu, Zhiyun Ge, Jin Zhang, Lefu Lan, Caiguang Yang, Hao Chen*, Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa, Molecular Microbiology, 2016, 100(5): 5-16

6  Yafeng He, Jian Yuan, Yuchen Qiao, Dan Wang, Weizhong Chen, Xichun Liu, Hao Chen*, Zijian Guo*, The role of carrier ligands of platinum(II) anticancer complexes in the protein recognition of Pt–DNA adducts, Chemical Communications, 2015, 51(74): 14064-14067

7  Yafeng He, Yin Ding, Dan Wang, Wanjun Zhang, Weizhong Chen, Xichun Liu, Weijie Qin, Xiaohong Qian, Hao Chen*, Zijian Guo*, HMGB1 bound to cisplatin–DNA adducts undergoes extensive acetylation and phosphorylation in vivo, Chemical Science, 2015, 6(3): 2074-2078

8  Xing Liu, Xiaoxu Sun, Youcong Wu, Cen Xie, Wenru Zhang, Dan Wang, Xiaoyan Chen, Di Qu, Jianhua Gan, Hao Chen, Hualiang Jiang, Lefu Lan*, and Caiguang Yang*, Oxidation-sensing regulator AbfR regulates oxidative stress responses, bacterial aggregation, and biofilm formation in Staphylococcus epidermidis, Journal of Biological Chemistry, 2013, 288:3739-3752

9  Mi Bao, DanWang, Shengyan Liu, Lili Kuang, Jian Sun, Fan Wang*,Yanxuan Wen, Electrodeposition and electrocatalytic activity of Cu2O film on stainless steel substrate, Applied Surface Science, 2012, 258:8008-8014

10  Fan Wang *, Haiqiu Wu, Ziting Lin, Shuaiyuan Han, Dan Wang, Ying Xue, Yunlong Sun, Jian Sun, Bin Li, Shape evolution of Cu-doped Mn3O4 spinel microcrystals: influence of copper content, Materials Research Bulletin, 2010, 45:1567-1573