施建成

2020年05月14日 浏览量: 评论(0) 来源: 化学与材料学院 作者: 化学与材料学院

施建成,男,博士,教授, 硕士生导师

专业方向:①药物分子设计;

②量子化学计算。

联系方式:

wyc666999@sina.cn

教育与研究经历

1999.9-2002.7 上海师范大学 生命与环境科学学院,硕士。

2003.9-2007.3 北京理工大学 理学院, 博士。

2007.3-至今, 南宁师范大学 化学与材料学院,教授(2010)。

本人从博士期间至今一直致力于计算化学方面的研究,具有较强的科研能力和扎实的专业理论知识,已经取得了一定的科研成果。目前,在南宁师范大学化学与材料学院主要从事基于生物靶标结构的药物分子设计、分子对接、三维定量构效关系(3D-QSAR)和密度泛函理论(DFT)方法的科研工作。近年来,研究成果已在《Chemcal Physics Letters》,《Molecular Simulation》,《Physical Biology》,《Journal of Theoretical Biology》,《Phys. Scr.》,《Biosystems》,《International Journal of Theoretical Physics》,《Cogn. Neurodyn.》和《Acta Biotheor》等国内外著名SCI期刊上发表25篇论文。主持广西自然基金1项,参与国家自然基金2项。

教学情况

承担本科生的《结构化学》、《物理化学》和研究生的《计算机在高分子科学中的应用》课程的教学工作。在教学工作中,根据不同的教学内容和不同的班级指导学生的学法,精心设计教学方法,突出重点、分散难点,能充分运用现代教育技术辅助教学,积极探索提高教学实效的新渠道和新手段,尝试把翻转课堂和混合式教学模式的理念运用于各门课程教学中。同时注重促进理论与实践的渗透和互动,也注重把本学科的最新发展动态和前沿知识传授给学生以充分调动学生学习的积极性。每年的教学评教都获得优秀的成绩。获得过南宁师范大学优质课教学比赛奖。指导的本科毕业论文获得过广西高校化学化工类论文及设计竞赛一等奖和优秀奖。指导的硕士研究生获得过优秀硕士毕业生的称号。

                          主要学术论文

Jiancheng Shi, Chusheng Huang, “Cooperative effect of random and time-periodic coupling strength on synchronization transitions in one-way coupled neural system: mean field approach”. Cognitive Neurodynamics. 2017, 11: 383-390.

Jiancheng Shi, Wentong Tu, Chusheng Huang. “Molecular docking and molecular dynamics simulation approaches for identifying new lead compounds as potential AChE inhibitors”. Molecular Simulation. 2017, 43: 102-109.

Jiancheng Shi, Tao Dong, Chusheng Huang, “External noise and external signal induced transition of gene switch and coherence resonance in the genetic regulatory system”. Acta Biotheor. 2017, 65: 135–150.

Jiancheng Shi, Wentong Tu, Chusheng Huang, “Structural insight into the design on oleanolic acid derivatives as potent protein tyrosine phosphatase 1B inhibitors”. Chinese J. Struct. Chem. 2017, 36: 1063-1076.

Jiancheng Shi, Chusheng Huang, “Inducement and enhancement of multiple coherence resonances in unidirectionally coupled neural systems: random and time-periodic coupling strength”. Pramana-Journal of physics 2017, 89: 83.

Jiancheng Shi, Dan Zhao, Chusheng Huang, “A Mechanism-based 3D-QSAR and DFT Approach for the Prediction of H5N1 Entry Inhibitory Potency of 3-O-β-chacotriosyl Ursolic Acid Derivatives”. Chinese J. Struct. Chem. 2017, 36: 1987-1999.

Huang Chu-Sheng, Tu Wen-Tong, Shi Jian-Cheng, “Molecular Docking and Design of Novel Heterodimers of Donepezil and Huperzine Fragments as Acetylcholinesterase Inhibitors”, Chinese J. Struct. Chem., 2016, 35: 839-848.

8. Jiancheng Shi, Wentong Tu, Jiarong Sheng and Chusheng Huang, “MTDLs Design on AChE (Acetylcholinesterase) and β-Secretase (BACE-1): 3D-QSAR and Molecular Docking Studies”, Journal of Pharmacy and Pharmacology, 2015, 3: 489-501.

9. Chusheng Huang, Jiancheng Shi, Hongxing Liu, Qian Chen and Hongxia Duan, “Facile Syntheses of 3-Isopentenyl Flavone and 3-Geranyl Flavone”, Chem. Res.  Chinese Universities, 2012, 28: 994-998. 

10. Chusheng Huang, Hongxing Liu, Jiancheng Shi, Sen Lin and Hongxia Duan, “Total Synthesis of 5, 7-Dihydroxy-3-isopentenylflavone and 5-Hydroxy-3-isopentenylflavone Natural Compounds”, Chemical journal of Chinese universities, 2012, 33: 1978-1983. 

11. Jiancheng Shi, Chusheng Huang,Tao Dong, “High-frequency and low-frequency effects on vibrational resonance in a syntheticgene network”, Physical Biology, 2010, 7: 036006 (1-7). 

12. Jiancheng Shi, Tao Dong, “Control of Vibrational Biresonance in a Calcium Ion System”, Acta Phys. Chim. Sin., 2010, 26: 487-494. 

13. Jiancheng Shi, Min Luo, “Effect of Colored Noise on Circadian Oscillation and Internal Signal Stochastic Resonance in Biological Clock System”, Prog. Biochem. Biophys. 2010, 37(1): 85-93. 

14. Jiancheng Shi, Tao Dong, Chusheng Huang, “The synchronization of calcium oscillations in coupled hepatocytes: The mean field coupling”, Chem. Phys. Lett. 2010, 495: 270-274. 

15. Jiancheng Shi, “Signal transduction and amplification in a circadian oscillator: Interaction between two colored noises”, J. Theor. Biol. 2010, 265: 565-571.

16. Jiancheng Shi, “The cooperation effect of noise and an external signal on implicit and explicit coherence resonances in the brusselator system”, Phys. Scr. 2010, 81:  045003 (1-6). 

17. Jiancheng Shi, Min Luo, Chusheng Huang,“Signal transmission in two-way coupled neural system: system size effect”, Ind. J. phys., 2010, 84: 1229-1239. 

18. Jiancheng Shi, Min Luo, Tao Dong, “The selectivity of noise and coupling for coherence biresonance and array-enhanced coherence biresonance in coupled neural systems”, Biosystems, 2009, 98: 85-90.

19. Jiancheng Shi, Xiufeng Lang, “Enhancement of internal stochastic resonance in Neurospora circadian clock system: multiplicative and additive noises effects”. Acta physica sinica, 2009, 58: 4281-4287.

20. Jiancheng Shi, Min Luo, Tao Dong, “Inducement and enhancement of coherence resonance in chemical oscillation system”, Chemical journal of Chinese universities, 2009, 30: 1856-1860. 

21. Jiancheng Shi, Qianshu Li, “The enhancement and sustainment ofcoherence resonance in two-way coupled brusselator system”, Physica D, 2007, 225: 229-234. 

22. Jiancheng Shi, Qianshu Li, “Sustainment and Controlment of Noise-Induced Circadian Oscillations in Neurospora: Noise and External Signal Effect”, International Journal of Theoretical Physics, 2007, 46: 2351-2365. 

23. Qianshu Li, Jiancheng Shi, “Cooperative effects of parameter heterogeneity and coupling on Coherence resonance in unidirectional coupled brusselator system”, Physics Letters A, 2007, 360: 593-598. 

24. Wang Guihua, Harrison A, Li Xia, Whittaker G, Shi Jiancheng, Wang Xin, Yang Haifeng, Cao Peigen., Zhang Zongrang. Study of the adsorption of benzimidazole and 2-mercaptobenzothiazole on an iron surface by confocal micro-Raman spectroscopy, Journal of Raman Spectroscopy, 2004, 35(12): 1016-1022.  

25. Guihua Wang, Jiancheng Shi, “Surface-enhanced Raman scattering of imidazole adsorbed on iron surface”, Journal of Raman Spectroscopy, 2002, 33: 125-130.